You might not be surprised to hear that Take-Two is investigating Natal. Ben Feder (CEO and director of T2) has, however, given us reason to doubt whether his company has anything in the pipeline for Sony's motion controller.

In an earnings call following T2's financial results an analyst asked (among other things), "what does the launch of Project Natal and Sony’s motion sensor mean for Take-Two next year and are you guys already working on titles that are going to utilize those capabilities?"

Feder responded with, "Natal motion sensor, yes, we have dev kits. Yes we are working on them. Obviously can’t comment on games that we haven’t announced but those dev kits are embedded in all of our studios or just about all of our studios and everybody is working with them to try to figure out new ways in which we can innovate and create the kind of content that this company is famous for. So yes, we are working on it."

You'll notice that there's no mention of the PS3 motion controller in there...

^{Source: Seeking Alpha}